AI資安組, 資訊組, 醫學資電組

楊正宏CHENG-HONG YANG - AI資安組, 資訊組, 醫學資電組

英文名字: Cheng-Hong Yang
分  機: 15639
學  歷: 美國北達科達州立大學資訊科學系  博士
專  長: 人工智慧





1. 人工智慧 (Artificial Intelligence)
2. 智慧計算(Intelligent Computing)
3. 機器學習(Machine Learning)
4. 資料探勘(Data Mining)
5. 巨量資料分析(Big Data)
6. 資料檢索(Information Retrieval)
7. 醫療資訊(Information Retrieval)
8. 影像辨識(Image Recognition)
9. 嵌入式系統開發(Embedding System Development)
10. 醫學工程(Medical Engineering)



1. 101年: (一) 建構新穎的原核生物操作組預測方法及分析平台 (100-2221-E-151-051-MY2);(二) 基因相互作用分子序列辨識及其預測與系統開發之研究 (100-2221-E-151-049-MY3)

2. 100年: (一) 建構新穎的原核生物操作組預測方法及分析平台 (100-2221-E-151-051-MY2);(二) 基因相互作用分子序列辨識及其預測與系統開發之研究 (100-2221-E-151-049-MY3)

3. 99年: (一) 新穎的系統生物學方法開發癌症生物標誌–開發新穎的癌症生物標誌的基因表現連續分析演算法及系統 (99-2221-E-151-056-);(二) 基於粒子最佳化方法之PCR-RFLP引子設計及系統開發 (99-2622-E-151-019-CC3)。

4. 98年: (一) 基於NCBI各物種之SNP序列RFLP分析系統(NSC98-2622-E-151-024-CC3),建構新穎的附基因體圖譜的整合平台(NSC98-2221-E-151-040-);(二) 基於遺傳演算法設計有效的PCR-CTPP引子及系統之開發(NSC98-2622-E-151-001-CC2)。

5. 97年: (一) 驗證與應用全基因體oligo晶片的口腔癌生物標誌(NSC 97-2311-B-037-003-MY3),染色體轉位識別分析系統之研發(NSC97-2311-B-037-003-MY3)。



1.Chuang, L.-Y., H.-C. Huang, M.-C. Lin, and Cheng-Hong Yang, “Particle Swarm Optimization with Reinforcement Learning for the Prediction of CpG Islands in the Human Genome”, PLoS ONE, 6(6):e21036, 2012,06.(SCI)

2.Chang, H.-W., L.-Y. Chuang, M.-T. Tsai, and Cheng-Hong Yang, “The Importance of Integrating SNP and Cheminformatics Resources to Pharmacogenomics”, Current Drug Metabolism, Pubmed ID:22591347, 2012,05.(SCI)

3.Yang, Cheng-Hong, Y.-H. Cheng, C.-H. Yang, and L.-Y. Chuang,”Mutagenic Primer Design for Mismatch PCR-RFLP SNP Genotyping using a Genetic Algorithm”, IEEE-ACM Transactions on Computational Biology and Bioinformatics, 2012,05.(SCI)




1. 人工智慧
2. 智慧計算
3. 機器學習
4. 資料探勘
5. 巨量資料分析
6. 資料檢索
7. 醫療資訊
8. 影像辨識
9. 嵌入式系統開發
10. 醫學工程




1.     建構新穎的附基因體圖譜的整合平台 (98-2221-E-151-040-),2009/08/01 ~ 2010/07/31,主持人。

2.     基於NCBI各物種之SNP序列RFLP分析系統(98-2622-E-151-024-CC3) ,2009/11/01~ 2010/10/31,主持人

3.     驗證與應用全基因體oligo晶片的口腔癌生物標誌 (97-2311-B-037-003-MY3),2008/08/01 ~ 2011/07/31,共同主持人。

4.     基於遺傳演算法設計有效的PCR-CTPP引子及系統之開發(1/2) (97-2622-E-151-008-CC2),2008/08/01~ 2009/07/31,主持人。

5.     華語文教學人員數位教學能力培訓 (96-3114-P-084-005-Y12),2007/10/01 ~ 2008/12/31,主持人。

6.     染色體轉位識別分析系統之研發(96-2622-E-151-019-CC3),2007/11/01 ~ 2008/10/31,主持人。




  1. Cheng-Hong Yang, L.-Y. Chuang, and L.-D. Lin, Detecting SNP-SNP interactions in imbalanced case-control study, IEEE Access, Vol. 7: 143036 – 143045, Sept. 2019.
  2. Cheng-Hong Yang, S.-F. Liu, C.-Y. Lin, and C.-Y. Chang, An interactive digital somatosensory game system that implements a decision tree algorithm, IEEE Access, Vol. 7: 140190 – 140196, Sept. 2019.
  3. -H. Chen, L.-Y. Chuang, K.-C. Wu, Y.-H. Wang, T.-Y. Shieh, J.-C. Jim Sheu, H.-W. Chang, and Cheng-Hong Yang, Application of simulation-based CYP26 SNP environment barcodes for evaluating the occurrence of oral malignant disorders by odds ratio-based binary particle swarm optimization: A case-control study in the Taiwanese population, PLoS ONE, 14(8): e0220719. Aug. 2019.
  4. Cheng-Hong Yang, L.-Y. Chuang, Y.-D. Lin, Y.-S. Lin, Effective Hybrid Approach for Protein Structure Prediction in a Two-Dimensional Hydrophobic-Polar Model, Computers in Biology and Medicine, 13:103397, Aug. 2019.
  5. Hao, B.-C. Cheng, H.-T. Yang, C.-H. Wu, Y.-Y. Lei, M.-C. Chao, P.-Y. Wang, L.-C. Kuo, S.-H. Moi, Cheng-Hong Yang, J.-B. Chen, Time-varying serum albumin levels and all-cause mortality in prevalent peritoneal dialysis patients Time-varying serum albumin levels and all-cause mortality in prevalent peritoneal dialysis patients: A 5-year observational study, BMC Nephrology, 10;20(1):254, July 2019.
  6. -B. Chen, W.-C. Lee, L.-C. Li, S.-H. Moi, and Cheng-Hong Yang, Effect of Clinical Factors on Trajectory of Functional Performance among Patients Undergoing Hemodialysis, Nephrology Dialysis Transplantation, 34(S1), SP081, June 2019.
  7. Cheng-Hong Yang, S.-H. Moi, F. Ou-Yang, L.-Y. Chuang, M.-F. Hou, and Y.-D. Lin, Identifying Risk Stratification Associated with a Cancer for Overall Survival using Deep Learning-Based CoxPH, IEEE Access, 2916586, May 2019.
  8. Hao, Cheng-Hong Yang, H.-T. Yang, C.-H. Wu, Y.-Y. Lei, Y.-P. Wu, W.-T. Lin, T. T.-Y. Chiou, J.-B. Chen, Comparison of Solute Clearance, Hospitalization Rate, and Aortic Arch Calcification between Online Hemodiafiltration and High-Flux Hemodialysis: A 6-Year Observational Study, Kidney & Blood Pressure Research, 44(2):264-276, Apr. 2019.
  9. Cheng-Hong Yang, K.-C. Wu, L.-Y. Chuang, H.-W. Chang, Decision theory-based COI SNP tagging approach for 126 Scombriformes species tagging, Frontiers in Genetics, Vol. 10, Article ID 259, Apr. 2019.
  10. Cheng-Hong Yang, G.-Y. Chen, S.-H. Moi, F. Ou-Yang, M.-F. Hou, L.-Y. Chuang, Relationship between clinicopathologic variables in breast cancer overall survival using biogeography-based optimization algorithm, BioMed Research International, Volume 2019, Article ID 2304128, Apr. 2019.
  11. C-H. Chiu, C.-Y. Wang, S.-H. Moi, C.-H. Wu, Cheng-Hong Yang, J.-B. Chen. Comparison of tunneled central venous catheters and native arteriovenous fistulae by evaluating the mortality and morbidity of patients with prevalent hemodialysis, Journal of the Formosan Medical Association, 118(4): 807-814, Apr. 2019.
  12. Cheng-Hong Yang, L.-Y. Chuang, and L.-D. Lin, Multiple-Criteria Decision Analysis–Based Multifactor Dimensionality Reduction for Detecting Gene–Gene Interactions, IEEE Journal of Biomedical and Health Informatics, 23(1): 416-426, Jan. 2019.
  13. Cheng-Hong Yang, Hsueh-Wei Chang, Yu-Huei Cheng and Li-Yeh Chuang (2009), Novel generating protective single nucleotide polymorphism barcode for breast cancer using particle swarm optimization, Cancer Epidemiology, Vol. 33, No. 2, pp. 147-154.
  14. Cheng-San Yang, Cheng-Huei Yang, Li-Yeh Chuang and Cheng-Hong Yang (2009), A wireless internet interface for person with physical disability, Mathematical and Computer Modelling, Vol. 50, No. 1-2, pp. 72-80.
  15. Chuang, L.-Y., C.-H. Ke, H.-W. Chang, and Cheng-Hong Yang (2009), A two stage feature selection methods for gene expression data, OMICS: A Journal of Integrative Biology, Vol. 13, No. 2, pp. 127-137.
  16. Chang, H.-W., L.-Y. Chuang, Y.-H. Cheng, C.-H. Ho, and Cheng-Hong Yang (2009), Seq-SNPing: multiple-alignment tool for SNP discovery, SNP ID identification and RFLP genotyping, OMICS: A Journal of Integrative Biology, Vol. 13, No. 3, pp. 253-260.
  17. Hsueh-Wei Chang, Li-Yeh Chuang, Yan-Jhu Chang, Yu-Huei Cheng, Yu-Chen Hung, Hsiang-Chi Chen and Cheng-Hong Yang (2009), LD2SNPing: Linkage disequilibrium plotter and RFLP enzyme mining for tag SNPs, BMC Genetics, Vol. 10, No. 26.
  18. Hsueh-Wei Chang, Li-Yeh Chuang, Yu-Huei Cheng, Yu-Chen Hung, Cheng-Hao Wen, De-Leung Gu and Cheng-Hong Yang (2009), Prim-SNPing: a primer designer for cost-effective SNP genotyping, BioTechniques, Vol. 46, No. 6, pp. 421-431.
  19. Cheng-Hong Yang, Yu-Huei Cheng, Li-Yeh Chuang and Hsueh-Wei Chang (2009), Specific PCR product primer design using memetic algorithm, Biotechnology Progress, Vol. 25, No. 3, pp. 745-753.
  20. Gau-Tyan Lin, Hung-Fu Tseng, Cheng-Hong Yang, Ming-Feng Hou, Li-Yeh Chuang, Hsiao-Ting Tai, Ming-Hong Tai, Yu-Huei Cheng, Cheng-Hao Wen, Chih-Shan Liu, Chih-Jen Huang, Chun-Lin Wang and Hsueh-Wei Chang (2009), Combinational Polymorphisms of Seven CXCL12-related Genes Are Protective against Breast Cancer in Taiwan, OMICS: A Journal of Integrative Biology, Vol. 13, No. 2, pp. 165-172.
  21. Cheng-Hong Yang, Li-Yeh Chuang, Yu-Huei Cheng, Cheng-Hao Wen and Hsueh-Wei Chang (2009), Dynamic Programming for Single Nucleotide Polymorphism ID Identification in Systematic Association Studies, The Kaohsiung Journal of Medical Sciences, Vol. 25, No. 4, pp. 165-176.
  22. Hsueh-Wei Chang, Cheng-Hong Yang, Chang-Hsuan Ho, Cheng-Hao Wen and Li-Yeh Chuang (2009), Generating SNP barcode to evaluate SNP–SNP interaction of disease by particle swarm optimization , Computational Biology and Chemistry, Vol. 33, No. 1, pp. 114-119.
  23. Cheng-San Yang, Ming-Long Yeh, Hsiu-Chen Huang, Li-Yeh Chuang and Cheng-Hong Yang (2009), An Improved Chinese Phonetic Morse Code Key-In System for Severely Disabled Individuals, Journal of the Chinese Institute of Engineers, Vol. 32, No. 1, pp. 129-135.